Tacrolimus-Induced Salt Losing Nephropathy Resolved After Conversion to Everolimus
نویسنده
چکیده
T is one of the most commonly used immunosuppressive drugs but tacrolimus-induced severe symptomatic hyponatremia is not a well-documented issue in kidney transplant patients. In our current report, we describe a case of tacrolimus-induced hyponatremia in a living donor kidney recipient in whom any other potential cause of hyponatremia was excluded, and tacrolimus-induced salt losing nephropathy was resolved after conversion to everolimus.
منابع مشابه
ایمنی و اثربخشی داروی اورولیموس در مقایسه با تاکرولیموس و سیرولیموس در جلوگیری از رد پیوند کلیه: یک مطالعه مروری نظاممند و متاآنالیز
Background: Everolimus is an immunosuppressive agent with a novel mode of action but has a different clinical role with calcineurin inhibitors (CNI). The aim of this study was to evaluate the safety and effectiveness of everolimus compared with sirolimus and tacrolimus in preventing kidney transplantation rejection. Methods: Search was conducted for finding randomized clinical trials (RCT) unt...
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Background and aims: Immunosuppressive regimens are a key component for successful kidney transplantation. This systematic review aimed to assess the efficacy and safety of combination therapy of everolimus with tacrolimus in kidney transplantation recipients. Methods: Results were limited to English-language articles. Trials where recipients received ano...
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While tacrolimus and everolimus have common metabolic pathways through CYP3A4/5, tacrolimus is metabolized solely by CYP3A4 in recipients with the CYP3A5*3/*3. The purpose of this study was to evaluate how the area under the blood concentration-time curves (AUC) of tacrolimus could be predicted based on CYP3A5 genotype and the AUC of everolimus in renal transplant patients taking both drugs. Th...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2015